Our Mission

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Today’s illicit drugs are being weaponized. Existing overdose treatments are no match for their lethal spread.

America’s defenses to prevent overdose must adapt & evolve for the modern era. OVAX develops proven vaccine technologies to stop fentanyl overdoses before they can begin.

Madeline

Forever 21

Hunter

Forever 15

De Kari

Forever 1

Alex

Forever 25

James

Forever 19

Damien

Forever 16

Russell

Forever 34

Carson

Forever 16

Ariel

Forever 15

Anthony

Forever 20

Christopher

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Rain

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Cassius

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Luke

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Landon

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Romel

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Alexis

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Carly

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Kadan

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Lilliana

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Johnny

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Deenilson

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Joel

Forever 19

Joey

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Alexia

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Brady

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Dylan

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Michael

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Eliot

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Arnold

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Fentanyl is the single deadliest drug threat our nation has ever encountered.

DEA Administrator

ー Anne Milgram

Fentanyl is the #1 Killer of US Adults aged 18 to 45

Pen for size comparison

Lethal Dose of Fentanyl

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Fentanyl poisoning occurs when fentanyl moves from a victim’s bloodstream into the brain, triggering the body’s lungs to stop breathing.

Narcan (naloxone) must be available and administered immediately by a bystander or first responder to reverse an overdose, but it rarely is.

Min 0

Fentanyl ingested

2 milligrams, equivalent to 10-15 grains of salt.

Min 3

Breathing slows

Breathing begins to slow and then stops.

Min 10

Patient passes away

Victim passes away if emergency response takes too long.

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OVAX, developed using established vaccine technologies, prevents fentanyl from entering your brain to keep you breathing upon exposure.

A protective barrier that prevents fentanyl from reaching the brain.

Unlike current emergency response solutions, OVAX is taken annually, offering a robust defense system that immediately neutralizes fentanyl upon exposure.

Prevents a fentanyl high
Keeps you breathing
Removes fentanyl from the body

Our mission is to save lives from overdose by focusing on three key principles: prediction, prevention, and protection.

Read about our scientific co-founders

Clinical Trials

Pre‑discovery

Discovery

Pre‑clinical

Phase 1

Phase 2

Phase 3

Houston Project // OVAX-100

Fentanyl Overdose Vaccine employing dMLT adjuvant system

Preparing Phase 1 Trials

Boston Project // OVAX-200

Fentanyl Overdose Vaccine based on the PVP-037 adjuvant system

Pre-Clinical

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Clinical Trials

Pre‑discovery

Discovery

Pre‑clinical

Phase 1

Phase 2

Phase 3

Houston Project // OVAX-100

Fentanyl Overdose Vaccine employing dMLT adjuvant system

Preparing Phase 1 Trials

Boston Project // OVAX-200

Fentanyl Overdose Vaccine based on the PVP-037 adjuvant system

Pre-Clinical

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Colin Haile

Scientific Co-Founder & Advisor

Dr. Colin Haile co-invented the OVAX-100 vaccine and is a leading national expert on fentanyl overdose solutions. He is a former research fellow at Yale University School of Medicine where he focused on addiction disorders.

Ofer Levy, MD, PhD

Scientific Co-Founder & Medical Advisor

Dr. Ofer Levy co-invented OVAX-200 and directs the Precision Vaccines Program at Boston Children’s Hospital. He serves on the U.S. Food & Drug Administration Vaccines and Related Biologic Products Advisory Committee (VRBPAC) and is a Professor of Pediatrics at Harvard Medical School.

David Dowling, PhD

Scientific Co-Founder

Dr. David Dowling co-invented OVAX-200 and is a leading immunologist and vaccinologist. He is a faculty member in the Precision Vaccine Program at Boston Children's Hospital and an instructor of Pediatrics at Harvard Medical School.

Meet the OVAX team