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Today’s illicit drugs are being weaponized. Existing overdose treatments are no match for their lethal spread.

America’s defenses to prevent overdose must adapt & evolve for the modern era. OVAX develops proven vaccine technologies to stop fentanyl overdoses before they can begin.

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Fentanyl is the single deadliest drug threat our nation has ever encountered.

DEA Administrator
ー Anne Milgram
Fentanyl is the #1 Killer of US Adults aged 18 to 45

Pen for size comparison
Pen for size comparisonPen for size comparison
Lethal Dose of Fentanyl
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Fentanyl poisoning occurs when fentanyl moves from a victim’s bloodstream into the brain, triggering the body’s lungs to stop breathing.

Narcan (naloxone) must be available and administered immediately by a bystander or first responder to reverse an overdose, but it rarely is.

Min 0
Fentanyl ingested

2 milligrams, equivalent to 10-15 grains of salt.

Min 3
Breathing slows

Breathing begins to slow and then stops.

Min 10
Patient passes away

Victim passes away if emergency response takes too long.

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OVAX, developed using established vaccine technologies, prevents fentanyl from entering your brain to keep you breathing upon exposure.

A protective barrier that prevents fentanyl from reaching the brain.

Unlike current emergency response solutions, OVAX is taken annually, offering a robust defense system that immediately neutralizes fentanyl upon exposure.

  • Prevents a fentanyl high
  • Keeps you breathing
  • Removes fentanyl from the body
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Our mission is to save lives from overdose by focusing on three key principles: prediction, prevention, and protection.

Read about our scientific co-founders
Clinical Trials
Houston Project // OVAX-100

Fentanyl Overdose Vaccine employing dMLT adjuvant system

Preparing Phase 1 Trials

Boston Project // OVAX-200

Fentanyl Overdose Vaccine based on the PVP-037 adjuvant system

Pre-Clinical

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Colin Haile
Colin Haile
Scientific Co-Founder & Advisor

Dr. Colin Haile co-invented the OVAX-100 vaccine and is a leading national expert on fentanyl overdose solutions. He is a former research fellow at Yale University School of Medicine where he focused on addiction disorders.

Ofer Levy, MD, PhD
Ofer Levy, MD, PhD
Scientific Co-Founder & Medical Advisor

Dr. Ofer Levy co-invented OVAX-200 and directs the Precision Vaccines Program at Boston Children’s Hospital. He serves on the U.S. Food & Drug Administration Vaccines and Related Biologic Products Advisory Committee (VRBPAC) and is a Professor of Pediatrics at Harvard Medical School.

David Dowling, PhD
David Dowling, PhD
Scientific Co-Founder

Dr. David Dowling co-invented OVAX-200 and is a leading immunologist and vaccinologist. He is a faculty member in the Precision Vaccine Program at Boston Children's Hospital and an instructor of Pediatrics at Harvard Medical School.

Meet the OVAX team
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Fentanyl vaccine poised to be 'game changer' in fight against addiction
Fentanyl vaccine poised to be 'game changer' in fight against addiction

Feb 2, 2023

Governor Abbott Celebrates University Of Houston’s Groundbreaking Fentanyl Vaccine
Governor Abbott Celebrates University Of Houston’s Groundbreaking Fentanyl Vaccine

Dec 1, 2022

As COVID-19 fuels opioid deaths, researchers look to create an anti-opioid vaccine
As COVID-19 fuels opioid deaths, researchers look to create an anti-opioid vaccine

Oct 15, 2020

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